The edgewise compression strength of corrugated paperboard with oxidized starch, CMC, SAE synthesized surface sizing agent was studied. The effects of the amount of CMC, which was the dispersant, the mixed solution of oxidized starch and SAE, the proportion of oxidized starch and SAE, and the sizing temperature were investigated. The results showed that the combination of oxidized starch, CMC, SAE has better strengthening effect than used alone. The optimum technical strengthening conditions of corrugated board are 5%CMC, 9% mass fraction of mixed solution of oxidized starch and SAE, 1:10 mass ratio of oxidized starch and SAE, and sizing temperature 85 ℃.