In order to meet the needs of high-speed and high-precision registration and detection of large-area images printing in actual printing production, a new kind of printing image detection system was designed. In this system, many CCDs were used to acquire image information simultaneously, and the acquisition and transmission of image data were controlled by CPLD and PCI bus, and a new algorithm of image registration was adopted. The related programs and algorithms of this system were implemented by DDK and VC programming language. The experimental results showed that this system meets real-time need basically; its image registration is faster and more accurate; and its adaptability is stronger, so it has a certain practical value.