In food safety packaging, the performance of environmental protection and weather resistance of ink is more and more important. A kind of anti-UV nano-SiO-2 ink was studied, Nano-SiO-2 was prepared by the chemical precipitation method and characterized by XRD and Malvern Zetaszier Nano-ZS. The experimental results showed that the average size of nano-SiO-2 is under 100nm and it is a kind of amorphous powder. The homemade powder of nano-SiO-2, water-based ink and dispersants were mixed using ultra-wave dispersion, and the anti-UV water-based ink was prepared. The anti-UV experiment showed that the shading rate of the anti-UV ink is more than 90%. The ink has good application prospect in the area of food safety packaging and weather resistance.