The laminated film pouches for food packaging (two layers and three layers) were taken as object of study. Acetic acid was used as acid food stimulant. The overall migration of chemicals was studied by changing acid concentration, soaking time, and soaking temperature. The results showed that when 4% (V/V) or 16% (V/V), the overall migration of chemicals reaches the maximum; the overall migration is the minimum when acetic acid concentration is 10%(V/V); the overall migration of chemicals increases with soaking time; when the soaking temperature is 90 ℃, the overall migration of chemicals reaches the maximum.