Under different conditions, PE and PP films containing known amounts of antioxidants were soaked in 5 simulants of water, acetic acid (3 g/L), ethanol (volume fraction 10%,50%,95%), and olive oil, for certain time; the soaking solution was analyzed by Ultra Performance Liquid Chromatography. The relationship of migration amount and migration rate with migration time, food simulant temperature, food simulant properties, initial concentration of antioxidants, and the thickness of packaging material was studied. The results showed that the nature of food simulant has prominence influence on migration behavior; number of migrated antioxidant species, migration quantity and migration rate increases with temperature rising; migration quantity is higher and migration rate is lower for thicker film; the higher initial antioxidant concentration the more migration quantity and the lower migration rate.