The structure profile of pressure control system and control process for corrugated single facer was analyzed. A new pressure control system based on PLC S7-300 and SIWAREX U were designed to improve the corrugated cardboard quality. The working principle and hardware configuration of the system, calibration of SIWAREX U, and PLC software were introduced. Bonding pressure automatic control was realized, which was helpful for filing of production data; paperboard breaking poor bonding was avoided. The application prospect of the system in the corrugated package industry is promising.