Waterproof acrylic adhesive emulsion for soft packaging was synthesized by the method of multi-step seeded emulsion polymerization. Effects of the emulsifier, initiator, seed emulsion, and cross-linking monomers on adhesive properties were investigated respectively. Average particle size of emulsion was determined with the reaction time. The results showed that the functional monomers and emulsifier all participate in the copolymerization reactions; the absorption peaks of corresponding groups were obviously observed in infrared spectroscopy (FT-IR); acrylic emulsion adhesive has the best combination property when the dosage of reaction type emulsifier（COPS-1/AMPS=1∶1） is 2.0%~2.5wt%, the dosage of initiator(APS) is 0.45wt% , the dosage of seed emulsion is 8%~10wt%, the dosage of HDDA was 8wt%.