A fast screening and conformation method of phthalates in food contact materials based on liquid chromatography mass spectrometry using a linear ion trap-orbitrap hybrid instrument at high mass resolution (HPLC-LTQ-Oribitrap/MS) was developed. Accelerated solvent extraction method was applied for pretreatment of specimen. The operational parameters of ASE were optimized, such as extraction solvent, extraction temperature, static extraction time, flush volume and extraction cycles, to improve extraction efficiency of phthalates from food contact materials. High resolution mass spectrometry was applied to remove matrix interference. Full scanning of electrostatic field orbitrap was applied for quantification of compounds. Secondary mass spectrometric image of ion trap was applied to verify the unknown compounds. The results showed that the detection limit of phthalates were 1 ng/mL; the average recoveries is from 89.8% to 101.1%, with RSDs less than 8.0%. It was concluded that the method is simple, sensitive, and suitable for screening and confirmation of PAEs in food contact materials.