A high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was established and validated for simultaneous determination of 6 phthalates in food contact materials. The analytes were separated by an Agilent ZORBAX SB-C18 column with a mobile phase of methanol-water in gradient elution mode at the flow rate of 0.35 mL/min, in which the water phase was added 0.1% formic acid, the mass spectrometry worked in positive ion mode and MRM was adopted for quantification of the analytes. Besides, samples were extracted with accelerated solvent extraction, which significantly increased extraction efficiency of phthalates from food contact materials. The results showed a good linearity for 6 phthalates under the optimal conditions. The correlation coefficients were all more than 0.999; the limits of quantification of the method is 1.0 ng/mL for DPRP, BBP and 0.2 ng/mL for DCHP, DNHP, DHP, and DBEP; detection limit is 0.2 ng/mL for DPRP, BBP and 0.05 ng/mL for DCHP, DNHP, DHP, and DBEP; average recoveries of the 6 analytes at three spiked level ranged from 89.2% to 107.5%, with RSD less than 5.0%. The method is sensitive and simple, and is suitable for determination of the 6 phthalates in food contact materials.