A scheme of spot color ink accurate matching was designed and tested with X-RiteColor Master ink matching system solve the bottleneck problem of spot color ink accurate matching. The results showed that the establishment and optimization of database basic ink of color matching system, the collection of standard ink spectral spectrum, and the formula screening of facing the printing conditions and sample is the key to get satisfactory accurate spot color ink. The spot color ink accurate matching scheme is not only accurate matching, fast speed, and small color difference, but also suitable for actual production application.