A new design scheme of multifunctional end effector of palletizing robots was presented to satisfy the requirements of palletizing different types and specifications packages. Clamping of boxes, grasping of bags, pallets and pails, sucking of sheets were implemented by the clamping, grasping and sucking mechanisms driven by pneumatics. By analyzing and calculation, the structure of the end effector was designed and 3D CAD models were set up in SolidWorks platform based on general plan. Finally the cylinder type selection was completed and the pneumatic system of the end effector was designed. The general design is reasonable and meets the actual situations and requirements. It has a good application prospect.