Under different conditions, PVC films containing known amounts of plasticizers were soaked in 4 simulants of water, acetic acid (volume fraction 3%), ethanol (volume fraction 10%), and olive oil, for certain time; the soaking solution was analyzed by gas chromatography-mass spectrometry. The purpose was to study the relationship of migration amount and migration rate with migration time, food simulant temperature, food simulant properties, initial concentration of plasticizers, and the thickness of packaging material. The results showed that the nature of food simulant has prominence influence on migration action; number of migrated plasticizer species, migration quantity and migration rate increased with temperature rising; migration quantity is higher and migration rate is lower for thicker film; the higher initial plasticizer concentration the more migration quantity and the lower migration rate.