The DC motor control system with closed loop and speed regulation was designed with PIC18F2580 microcontroller as control unit for inking system of four-color offset press as basement. The circuit was designed in details. CAN bus interface circuit for communication to the console panel and PC, motor control and drive circuit, closed loop motor location feedback circuit, and PWM motor speed regulation circuit were designed with emphasis. The system software was compiled with C language. Experiment and actual operation showed that the system performs good driving performance, speed regulation and anti-electromagnetic interference performance. It can reduce costs and accelerate the automation and intelligent process of domestic offset. It has good market prospects.