Plastic packaging materials were digested by mixed acids of nitric acid and hydrogen peroxide solution using high pressure and closed microwave digestion technology. A method for the determination of Pb, Cd, As, Cr, Sb, Hg, Se, Ba, Ni, Sn, Sr and Tl in packaging materials by ICP-MS was established. The detection limits are in the range of 0.02～0.20 μg/L; the relative standard deviations are less than 10%; the recoveries are in the range of 88.0%～117.0%. The results proved that this method is simple, accurate, and reliable.