According to actual system of paper/plastic packaging-compound-food, diffusion equations were built based on one-dimensional Fick diffusion theory. Partition coefficient k-CP between paper and plastic was considered in the prediction model. Analytical solutions were obtained under specific initial condition〖JP2〗s and boundary conditions. In addition, the migration of migrant 1-hydroxycyclohexyl-1-phenyl ketone and benzyldimethyl ketal from paper-plastic materials 4015 and 3312 into different food simulant at 60 ℃ was studied. The experimental migration data based on experiment and calculated values based on the model were analyzed. The results showed that calculated values are higher than the experimental values. The higher calculated values were caused because of the “worst-case” values of DC. As far as this DC is concerned, this model can ensure the using safety of packaging.