The application of grey relational analysis method for comprehensive evaluation of design option was put forward according to characteristics of multi-factor and incomplete information in packaging product design option. Case analysis was carried out. Firstly, comparison sequence and reference sequence were established according to the value of the alternative option for the influential factor level; the correlation coefficient between the influencing factor and the optimal index of the alternative scheme was calculated; the weight of the evaluation index was combined to calculate the correlation degree; all alternative schemes were sequenced according to the correlation degree. The results showed that the method is featured by the clear ideas and low computational complexity, which is particularly suitable for optimization of multi-alternatives.