Design and Study of the Hypothermic Perfusion Transport System for Organs Based on Thermoelectric Cooling Compensation

CAO Ziqian; DANG Hangyu; ZUO Jinglong; GUO Ning; HAN Hengxin; LIU Jiayi; XU Yi

doi:10.19554/j.cnki.1001-3563.2026.07.023

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Packaging Engineering ›› 2026, Vol. 47 ›› Issue (7) : 193-202. DOI: 10.19554/j.cnki.1001-3563.2026.07.023

Automatic and Intelligent Technology

Design and Study of the Hypothermic Perfusion Transport System for Organs Based on Thermoelectric Cooling Compensation

CAO Ziqian, DANG Hangyu, ZUO Jinglong, GUO Ning, HAN Hengxin, LIU Jiayi, XU Yi^*

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Abstract

To address the limitations of existing organ transport devices, such as insufficient temperature control accuracy, non-uniform temperature distribution, and sensitivity to external disturbances, the work aims to develop a novel hypothermic perfusion transport system integrating phase-change cold storage with active thermoelectric cooling compensation, thereby improving temperature stability and reliability during organ transportation. A temperature control system composed of an EPP-VIP composite packaging structure, a phase-change thermal storage module, and a dual-TEC thermoelectric compensation unit was designed. A closed-loop control algorithm based on an STM32 microcontroller was implemented to achieve multi-level PWM regulation. The system performance was systematically evaluated through temperature control capability tests, thermal insulation experiments, and disturbance recovery tests. The system achieved rapid cooling and high-precision steady-state temperature control within the target perfusion range of 4-8 °C, maintaining a stable temperature of (6.0±0.3) °C. During continuous perfusion, the heart temperature was stably maintained within (6.0±1.0) °C for more than 66 h. Under disturbances such as lid opening and intermittent perfusion, temperature fluctuations remained below 2 ℃, and the steady-state temperature gradient inside the container was reduced by approximately 70% compared with that in static cold storage. The results demonstrate that the proposed system exhibits high temperature control accuracy, low energy consumption, fast dynamic response, and strong operational stability and the study provides a feasible technical reference for the development of next-generation high-performance organ perfusion transport systems.

Key words

perfusion transport system / thermoelectric compensation / phase-change energy storage / temperature control

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CAO Ziqian, DANG Hangyu, ZUO Jinglong, GUO Ning, HAN Hengxin, LIU Jiayi, XU Yi. Design and Study of the Hypothermic Perfusion Transport System for Organs Based on Thermoelectric Cooling Compensation[J]. Packaging Engineering. 2026, 47(7): 193-202 https://doi.org/10.19554/j.cnki.1001-3563.2026.07.023

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