Simultaneous Determination of Migration Levels of Three Cresol isomers in Food Contact Materials and Articles by Gas Chromatography-mass Spectrometry

ZENG Ming; A Wenwei; OU Yucheng; WU Zechun; LIANG Yue; LIANG Weifeng; FAN Yingying; CHEN Xiangying; LI Tianguang; LI Dan

doi:10.19554/j.cnki.1001-3563.2025.23.011

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Packaging Engineering ›› 2025, Vol. 46 ›› Issue (23) : 106-112. DOI: 10.19554/j.cnki.1001-3563.2025.23.011

Special Topic on Open Packaging Innovation Driving the Industrialization of Healthy and Nutritional Food

Simultaneous Determination of Migration Levels of Three Cresol isomers in Food Contact Materials and Articles by Gas Chromatography-mass Spectrometry

ZENG Ming¹, A Wenwei¹, OU Yucheng¹, WU Zechun¹, LIANG Yue¹, LIANG Weifeng¹, FAN Yingying¹, CHEN Xiangying¹, LI Tianguang², LI Dan^1,*

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Abstract

The work aims to evaluate the migration risk of o-cresol, m-cresol, and p-cresol by establishing a GC-MS method to determine the migration levels of these three cresol isomers in food contact materials and articles. For aqueous, acidic, and ethanol-containing food simulants, dichloromethane was used for extraction. For olive oil simulants, acetonitrile was employed. For chemical alternative solvents (95% ethanol and isooctane), direct liquid injection was adopted. The analysis was performed by gas chromatography-mass spectrometry (GC-MS) with external standard quantification. The three cresol isomers demonstrated good linearity within the concentration range of 0.30 to 3.0 mg/kg, with correlation coefficients exceeding 0.997. The method exhibited a limit of detection (LOD) of 0.1 mg/kg and a limit of quantification (LOQ) of 0.30 mg/kg for all analytes. Spiked recovery rates ranged from 85.5% to 110%, with relative standard deviations (RSD, n=6) between 1.9% and 9.4%. Testing and evaluation of actual samples demonstrated that this method exhibits high accuracy and reliability. This method is suitable for determining the migration levels of cresols in food contact materials and articles.

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food contact materials and articles / cresol / isomer / gas chromatography-mass spectrometry / migration

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ZENG Ming, A Wenwei, OU Yucheng, WU Zechun, LIANG Yue, LIANG Weifeng, FAN Yingying, CHEN Xiangying, LI Tianguang, LI Dan. Simultaneous Determination of Migration Levels of Three Cresol isomers in Food Contact Materials and Articles by Gas Chromatography-mass Spectrometry[J]. Packaging Engineering. 2025, 46(23): 106-112 https://doi.org/10.19554/j.cnki.1001-3563.2025.23.011

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