Determination of 10 PFASs in Food Contact Composite Films and Bags by GC-MS/MS

ZHANG Peilin; LING Guangyao; CHEN Yiguang; HE Guoshan; LIU Deyun; XIONG Xiaoting; LI Huiyong; LI Zerong

doi:10.19554/j.cnki.1001-3563.2025.19.029

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Packaging Engineering ›› 2025, Vol. 46 ›› Issue (19) : 275-282. DOI: 10.19554/j.cnki.1001-3563.2025.19.029

Automatic and Intelligent Technology

Determination of 10 PFASs in Food Contact Composite Films and Bags by GC-MS/MS

ZHANG Peilin, LING Guangyao, CHEN Yiguang^*, HE Guoshan, LIU Deyun, XIONG Xiaoting, LI Huiyong, LI Zerong

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Abstract

The work aims to establish a method for the determination of 10 PFASs in food contact composite films and bags and investigate the safety risks and regulatory compliance of these substances in such materials. With ethyl acetate as the extraction solvent, ultrasound-assisted extraction was employed to extract the substances of interest. Under acid catalysis, the alcohols were converted to their corresponding acetates with acetic anhydride. The target substances were detected with gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS). By examining the effects of catalyst type, derivatization reaction temperature, and reaction time on recovery rates, it was determined that sulfuric acid was the best catalyst, with derivatization by acetic anhydride at 60 °C for 60 minutes. The target substances were separated by a DB-5MS (30 m×0.25 mm×0.25 μm) capillary column with a temperature gradient method and GC-MS/MS multiple reaction monitoring (MRM) mode. Quantification was performed with the internal standard method. Experimental results showed that the 10 PFASs had good linearity in the concentration range of 10-200 μg/L, with correlation coefficients r≥0.997. The LODs ranged from 0.001 to 0.003 mg/kg, and the LOQs ranged from 0.003 to 0.01 mg/kg. In the matrix of composite food contact films and bags, the average recoveries at three spiked levels (high, medium, and low) ranged from 85.8% to 108.4%, with relative standard deviations (RSD, n=6) of 1.6% to 7.6%. This method is characterized by accurate qualitative and quantitative results, high sensitivity, good selectivity, and excellent reproducibility, making it suitable for the simultaneous detection of 10 PFASs in composite food contact films and bags.

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gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS) / PFASs / food contact composite films and bags

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ZHANG Peilin, LING Guangyao, CHEN Yiguang, HE Guoshan, LIU Deyun, XIONG Xiaoting, LI Huiyong, LI Zerong. Determination of 10 PFASs in Food Contact Composite Films and Bags by GC-MS/MS[J]. Packaging Engineering. 2025, 46(19): 275-282 https://doi.org/10.19554/j.cnki.1001-3563.2025.19.029

References

[1] 王亚韡, 张秋瑞, 于南洋, 等. 新污染物[J]. 化学进展, 2024, 36(11): 1607-1784.
WANG I, ZHANG Q R, YU N Y, et al.Emerging Pollutants[J]. Progress in Chemistry, 2024, 36(11): 1607-1784.
[2] 付成忠, 唐斌, 许榕发, 等. 北江流域饮用水源地全氟化合物的赋存特征及风险评价[J/OL]. 环境化学, 2025: 1-18(2025-05-16). https://kns.cnki.net/KCMS/detail/detail.aspxfilename=HJHX20250515009&dbname=CJFD&dbcode=CJFQ.
FU C Z, TANG B, XU R F, et al. Occurrence and Risk Assessment of Per-Fluoroalkyl Substances in Drinking Water Sources of the Beijiang River Basin[J/OL]. Environmental Chemistry, 2025: 1-18 (2025-05-16). https://kns.cnki.net/KCMS/detail/detail.aspxfilename=HJHX20250515009&dbname=CJFD&dbcode=CJFQ.
[3] 郝丽丽, 张磊, 宁钧宇, 等. PFOS与PFOA的毒性效应及其在我国普通人群中的内暴露研究进展[J]. 中国食品卫生杂志, 2022, 34(5): 1112-1121.
HAO L L, ZHANG L, NING J Y, et al.Toxic Effects of PFOS/PFOA and Their Internal Exposure in Chinese General Population[J]. Chinese Journal of Food Hygiene, 2022, 34(5): 1112-1121.
[4] 朱雨婷, 严文保, 徐菲, 等. 济南市社区居民血清中PFASs内暴露水平及影响因素[J]. 山东大学学报(工学版), 2023, 53(3): 147-154.
ZHU Y T, YAN W B, XU F, et al.Internal Exposure Levels and Influencing Factors of Serum Per- and Polyfluoroalkyl Substances in the Community Residents in Jinan City[J]. Journal of Shandong University (Engineering Science), 2023, 53(3): 147-154.
[5] 袁欣, 巴月, 樊境朴, 等. 孕期全氟烷基化合物暴露对胎儿生长发育影响的研究进展[J]. 环境化学, 2024, 43(11): 3642-3650.
YUAN X, BA Y, FAN J P, et al.Research Progress of Perfluoroalkyl Substances Exposure during Pregnancy and Its Effects on Fetal Growth[J]. Environmental Chemistry, 2024, 43(11): 3642-3650.
[6] 洪奥博, 杨盼, 陈达. 全氟化合物类暴露对育龄女性生殖健康影响的研究进展[J]. 环境与职业医学, 2021, 38(11): 1278-1283.
HONG A B, YANG P, CHEN D.Research Progress on Effects of Per and Polyfluoroalkyl Substances on Female Reproductive Health[J]. Journal of Environmental and Occupational Medicine, 2021, 38(11): 1278-1283.
[7] 龚乐敏, 卢忠武, 周钰涵. 全氟及多氟烷基化合物母婴暴露水平及对甲状腺功能影响的作用机制研究进展[J]. 环境与职业医学, 2024, 41(12): 1438-1445.
GONG L M, LU Z W, ZHOU Y H.Review on Per-and Polyfluoroalkyl Substances Exposure, Thyroid Function, and Mechanisms of Action in Mothers and Infants[J]. Journal of Environmental and Occupational Medicine, 2024, 41(12): 1438-1445.
[8] 熊围, 倪梦梅, 包汇慧, 等. 全氟辛酸和全氟辛烷磺酸的致癌性证据及机制研究进展[J]. 卫生研究, 2022, 51(2): 336-341.
XIONG W, NI M M, BAO H H, et al.Research Progress on Carcinogenicity Evidence and Mechanism of Perfluorooctanoic Acid and Perfluorooctane Sulfonic Acid[J]. Journal of Hygiene Research, 2022, 51(2): 336-341.
[9] 吴范宏, 叶璟, 李丹, 等. 氟足迹的评估方法、管控法规及治理策略[J]. 应用技术学报, 2025, 25(1): 15-25.
WU F H, YE J, LI D, et al.Assessment Methods, Regulatory Frameworks, and Governance Strategies for Fluorine Footprint[J]. Journal of Technology, 2025, 25(1): 15-25.
[10] 陈玲, 杨帆, 黄倩, 等. 食品接触制品中全氟和多氟化合物在各国的法规差异分析[J]. 现代食品, 2024, 30(7): 118-121.
CHEN L, YANG F, HUANG Q, et al.Analysis of Regulatory Differences between Countries for Perfluorinated and Polyfluoroalkyl Substances in Food Contact Products[J]. Modern Food, 2024, 30(7): 118-121.
[11] 何鹏, 何春兰, 陈忠. 食品接触材料中全氟/多氟烷基化合物的监管及对其替代品的思考[J]. 食品安全质量检测学报, 2020, 11(4): 1033-1039.
HE P, HE C L, CHEN Z.Regulatory Requirements of Per-and Polyfluoroalkyl Substances Used in Food Contact Materials and Insights on Their Alternatives[J]. Journal of Food Safety & Quality, 2020, 11(4): 1033-1039.
[12] 焦文清. 食品接触材料及食品中全氟化合物的污染特征及风险评估[D]. 杨凌: 西北农林科技大学, 2024.
JIAO W Q.Pollution Characteristics and Risk Assessment of Perfluorinated Compounds in Food Contact Materials and Food[D]. Yangling: Northwest A & F University, 2024.
[13] 郭庆园, 蔡汶静, 钟怀宁, 等. 食品接触材料中全氟和多氟化合物风险与管理[J]. 包装工程, 2017, 38(7): 53-58.
GUO Q Y, CAI W J, ZHONG H N, et al.The Risk Management of Perfluoroalkyl and Polyfluoroalkyl Substances from Food Contact Materials[J]. Packaging Engineering, 2017, 38(7): 53-58.
[14] 王振聚, 罗忻, 梁生康, 等. 高分辨质谱技术在全氟多氟化合物分析中的应用研究进展[J]. 分析测试学报, 2022, 41(6): 931-940.
WANG Z J, LUO X, LIANG S K, et al.Research Progress on Application of High-Resolution Mass Spectrometry in Analysis of PFAS[J]. Journal of Instrumental Analysis, 2022, 41(6): 931-940.
[15] 曹瑜, 钟泽辉, 唐聪. 食品接触材料中有害物质迁移的研究进展[J]. 包装工程, 2023, 44(15): 112-121.
CAO Y, ZHONG Z H, TANG C.Research Progress on the Migration of Harmful Substances in Food Contact Materials[J]. Packaging Engineering, 2023, 44(15): 112-121.
[16] 寇筱雪, 黄华军, 蔡汶静, 等. 食品接触材料检测技术新进展[J]. 分析测试学报, 2022, 41(3): 409-417.
KOU X X, HUANG H J, CAI W J, et al.New Progress on Detection Techniques for Food Contact Materials[J]. Journal of Instrumental Analysis, 2022, 41(3): 409-417.
[17] 陈潇江, 孙晶, 蒋丹艺, 等. 复杂基质中全氟和多氟烷基物质的残留检测方法研究进展[J/OL]. 理化检验-化学分册, 2025: 1-17(2025-05-07). https://kns.cnki.net/KCMS/detail/detail.aspxfilename=LHJH20250506001&dbname=CJFD&dbcode=CJFQ.
CHEN X J, SUN J, JIANG D Y, et al. Research Progress in Residual Detection Methods of Per- and Polyfluoroalkyl Substances in Complex Matrices[J/OL]. Physical Testing and Chemical Analysis (Part B (Chemical Analysis)), 2025: 1-17 (2025-05-07). https://kns.cnki.net/KCMS/detail/detail.aspxfilename=LHJH20250506001&dbname=CJFD&dbcode=CJFQ.
[18] 林勤保, 杨青华, 赵丹, 等. 食品接触用纸中全氟或多氟烷基化合物的来源、限量及检测技术研究进展[J]. 食品科学技术学报, 2024, 42(6): 25-34.
LIN Q B, YANG Q H, ZHAO D, et al.Research Progress on Source, Limitation and Detection Technology of Per- and Polyfluoroalkyl Substances in Food Contact Paper[J]. Journal of Food Science and Technology, 2024, 42(6): 25-34.
[19] 中华人民共和国海关总署. 纸制耐热材料中全氟和多氟化合物的测定: SN/T 5352—2021[S]. 北京: 中国海关出版社, 2021.
Determination of Perfluorinated and Polyfluorinated Compounds in Paper Heat-Resisting Material: SN/T 5352-2021[S]. Beijing: China Customs Press, 2021.
[20] 王春兰, 张海煊, 胡望霞, 等. 气相色谱-质谱法测定纺织品中10种挥发性全氟及多氟化合物[J]. 印染, 2023, 49(4): 58-62.
WANG C L, ZHANG H X, HU W X, et al.Determination of 10 Volatile Per-and Poly-Fluorinated Compounds in Textiles Using Gas Chromatography-Mass Spectrometry[J]. China Dyeing & Finishing, 2023, 49(4): 58-62.
[21] 李晓瞳, 高永刚, 罗忻, 等. 婴童纺织品中12种挥发性全氟和多氟化合物的同时测定及暴露评估[J]. 质谱学报, 2023, 44(2): 321-332.
LI X T, GAO Y G, LUO X, et al.Simultaneous Determination and Exposure Assessment of 12 Volatile Per- and Polyfluoroalkyl Substances in Infant and Child Textiles[J]. Journal of Chinese Mass Spectrometry Society, 2023, 44(2): 321-332.