Determination of 9 Bisphenol Epoxy Derivatives in Infant Food Packaging Materials

HONG Deng; SHEN Wentao; WANG Liangli; LI Yan; LI Bingjie; WANG Lulin; LIU Ting; HOU Jianbo; WANG Chen

doi:10.19554/j.cnki.1001-3563.2025.15.017

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Packaging Engineering ›› 2025, Vol. 46 ›› Issue (15) : 154-161. DOI: 10.19554/j.cnki.1001-3563.2025.15.017

Special Topic on Safety and Detection of Food Contact Materials

Determination of 9 Bisphenol Epoxy Derivatives in Infant Food Packaging Materials

HONG Deng^1,2*, SHEN Wentao¹, WANG Liangli¹, LI Yan¹, LI Bingjie¹, WANG Lulin¹, LIU Ting¹, HOU Jianbo^1,2, WANG Chen^1,2

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Abstract

The work aims to establish a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of 6 bisphenol A diglycidyl ethers and their derivatives, and 3 bisphenol F diglycidyl ethers and their derivatives in infant food packaging materials, providing technical support for the quality and safety control of these materials. Samples were ultrasonically extracted with tetrahydrofuran. Separation was achieved by an Eclipse XDB-C₁₈ chromatographic column with a methanol-0.15% formic acid solution mobile phase under gradient elution. Detection was performed through multiple reaction monitoring (MRM). Compounds were identified based on retention time and ion abundance ratio, and quantified with the external standard method. The 9 bisphenol epoxy derivatives exhibited good linearity in the range of 0.002-4 mg/kg, with correlation coefficients (R²) greater than 0.999. The method detection limits (MDLs) ranged from 0.002 to 0.2 mg/kg. The spike recovery rates were 83.9% to 99.1%, with relative standard deviations (RSDs) of 2.0% to 8.5%. This method is characterized by simple pretreatment and high sensitivity, and is suitable for the qualitative screening and quantitative analysis of bisphenol epoxy derivatives in food packaging materials.

Key words

bisphenol A diglycidyl ether (BADGE) / bisphenol F diglycidyl ether (BFDGE) / infant food packaging materials / packaging material / high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)

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HONG Deng, SHEN Wentao, WANG Liangli, LI Yan, LI Bingjie, WANG Lulin, LIU Ting, HOU Jianbo, WANG Chen. Determination of 9 Bisphenol Epoxy Derivatives in Infant Food Packaging Materials[J]. Packaging Engineering. 2025, 46(15): 154-161 https://doi.org/10.19554/j.cnki.1001-3563.2025.15.017

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