The work aims to ensure the safety and integrity of the specialized shielded transport container for the filter cartridge of the spent fuel pool purification system in a nuclear power plant under transportation accident conditions. The pre-processing functions of ANSYS and LS-PrePost were used to establish a finite element model for the shielded transport container, calculate the strain and deformation of the container with different drop postures under transportation accident conditions, and evaluate the structural integrity of the container. By comparing and analyzing the strain and deformation under 14 different drop postures, it could be concluded that the maximum plastic strain of the outer cylinder under the bottom 45° angle drop A and the bottom 70° angle drop A was greater than the material failure plastic strain of 0.45, while the maximum plastic strain of other components was less than the material failure plastic strain. Due to the double-layer structure of the cylinder, local failure on the outer side does not affect the structural integrity of the container, therefore under accident conditions, the quick-release wrench of the shielded transport container will not open, and the contents will not scatter, and the sealing surface can still maintain close contact and achieve sealing function.