The work aims to explore the design method of cushioning packaging information fusion based on the maximum acceleration-static stress curve to optimize the process and effect of cushioning packaging design. The maximum acceleration-static stress curve was characterized in the form of a universal function. By introducing optimal design criteria, a basic equation system for cushioning design was constructed. The mathematical and physical meanings of this equation system were explained. The cushioning packaging design based on the maximum acceleration-static stress curve was attributed to a problem of determining three design parameters with two constraint conditions. The stability constraints and basic equation system were utilized to derive the critical equation for cushioning instability. The maximum acceleration-static stress curve of the cushioning material was used as the basic information layer, and the fragility parameter [G] representing the cushioning design objective, the product bottom area parameter A representing the constraint conditions, and the cushioning instability critical equation were projected onto the basic information layer. By fusing multiple layers of information, the boundary diagram of buffer packaging information fusion design could be obtained, which enabled fast and accurate cushioning packaging design.