The work aims to clarify the transport reliability of wrapping packaging with degradable film for tobacco commercial logistics based on the current scenario of tobacco commercial logistics, so as to provide reference for green transformation and extensive application of tobacco commercial logistics packaging. Taking LDPE film shrink packaging as comparison, ANSYS finite element analysis software was introduced in the static analysis and random vibration simulation of degradable film wrapping packaging, based on the survey data from Xi'an Tobacco Logistics Distribution Center. The results showed that the maximum deformation amount of degradable films in wrapping packaging accounted for 1/5 of that in LDPE film shrink packaging under the same static load. In the horizontal random vibration simulation, the film on the top of the cigarette packs was the most vulnerable to vibration, and degradable films in wrapping packaging exhibited less deformation compared with LDPE film shrink packaging. And film deformation in the vertical random vibration mainly existed on the middle part of the cigarette pack, and the maximum deformation of degradable films in wrapping packaging was only 1/3 of that in LDPE film shrink packaging. In conclusion, the transport reliability of degradable film wrapping packaging is superior to LDPE film shrink packaging. The work may provide theoretical support and methodological reference for the process upgradation and green transformation of tobacco commercial logistics packaging.