The work aims to improve gas sampling equipment to address the issue of low fragility by designing the equipment packaging and validating the reliability of the packaging solution through simulation and testing. The fragility of the vulnerable components was determined through transient structural simulation analysis. The structure securing the fragile components was improved to enhance the overall fragility of the device. A buffer packaging was designed, and LS-DYNA was used to conduct drop simulation of the packaging. The reliability of the finite element analysis and the feasibility of the packaging solution were validated through actual drop tests. The overall fragility of the equipment before improvement was 18.5g. After adding the buffer structure, the fragility increased to 32.7g. Based on the buffer packaging solution designed after the equipment improvement, during drop tests from a height of 500 mm onto flat surfaces, edges, and corners, the maximum response acceleration experienced by vulnerable components was 17.4g for flat drops, with a maximum stress of 5.5 MPa, which was less than the fragility of 18.5g and the compressive strength of 6.9 MPa. The average error between the simulation and experimental results was less than 10%. The improvement made to the structure securing the fragile components enhances the overall fragility of the equipment, thereby reducing the difficulty of packaging design. This approach offers valuable insights for the packaging system design of precision instruments.