The work aims to develop an analytical method for determining the residual amount of 2,2,4,4- tetramethyl-1,3-cyclobutanediol Tritan plastic based on the assumption of 100% migration of the residue using a dissolution-precipitation-GC/MS method, so as to rapidly assess the maximum migration amount of the target substance. After dissolving the sample in hexafluoroisopropanol, ethanol was used as a precipitant to fully precipitate the polymer. The supernatant, after concentration and filtration, was analyzed by gas chromatography-mass spectrometry with external standard quantification. 2,2,4,4-tetramethyl-1,3-cyclobutanediol exhibited good linearity within the range of 0.080 to 40 mg/kg, with correlation coefficients all greater than 0.995. The limits of detection and limits of quantification of the method were 0.04 mg/kg and 0.080 mg/kg. The recoveries ranged from 92.5% to 105%, with the relative standard deviation (n=6) of 3.0%~5.0%. Testing and evaluation of actual samples demonstrated that the residue detection method had high accuracy and good reproducibility. In conclusion, this residue screening method can be used for rapid assessment of the migration level of 2,2,4,4-tetramethyl-1,3-cyclobutanediol in Tritan plastic products.