The work aims to improve the strength and permeability of medical coated dialysis cover paper, and enhance its application value in the field of medical packaging. The effects of drying temperature, drying time and the ratio of isolation coating and pore-forming agent on the air permeability, strength and surface properties of coated paper were studied. The results showed that when the drying temperature was 85 ℃ and the drying time was 15 minutes, the addition amount of pore-forming agent was 7% (the coating amount was about 2.0 g/m2), the permeability, transverse tensile index, longitudinal tensile index, transverse tear index and longitudinal tear index of composite insulating coated paper were 280 mL/min, 60.00 N.m/g, 97.30 N.m/g, 8.52 mN.m2/g, and 8.06 mN.m2/g, respectively. The permeability was greater than 200 mL/min after application of isolation coating and greater than 80 mL/min after application of hot melt coating. In conclusion, through the construction of the coated layer and the optimization of the process, the prepared coated dialysis cover paper has excellent air permeability, which provides a theoretical basis for the process of high strength and high permeability medical coated dialysis paper.