In response to challenges such as deformation due to moisture susceptibility, poor durability and non-reusability associated with the wooden crates of large sheet glass for railway transport, the work aims to design a secure, reusable, disassemblable, and bi-directional bare packed large sheet glass container transport frame for railway 35 t open-top container. The container transport frame was designed in accordance with the "Steel Structure Design Code" and the internal structure of open-top containers. Subsequently, adhering to the "Railway Cargo Loading and Reinforcement Rules," adverse loading conditions were considered to determine reinforcement solutions, and the forces acting on the container transport frame were calculated. Finally, the collaborative simulation techniques of SolidWorks and ANSYS were utilized to establish a CAE model of the glass container transport frame, and a finite element analysis under dynamic loading conditions was conducted. The stress values at the weakest points of the longitudinal, vertical, and lateral restraint components of the container transport frame were determined to be 186.44, 184.82, and 168.98 MPa, respectively. The corresponding deformation values were found to be 1.30, 0.36, and 0.75 mm, all in compliance with specified standards. The results indicate that the large sheet glass container transport frame is secure and reliable, effectively reducing glass breakage rates. It aligns with safety requirements for railway cargo transportation, providing a robust reference for the design of similar container transport frames for railway sheet goods.