The work aims to study the vibration and noise characteristics of the printing press during high-speed operation, so as to provide reference basis for noise suppression. The field test method and the finite element and boundary element method were used to investigate the noise and vibration characteristics of the printing press. Firstly, the field test of vibration and noise were carried out on the shell of the printing press unit under different working conditions. Then, the simulation software was used to establish the finite element-boundary element model. Finally, through simulation calculation, the sound radiation characteristics of the printing press were analyzed. The vibration and noise of the printing press were mainly concentrated in the low and medium frequency bands, and the sound radiation of the printing press was mainly generated from the unit shell, and there were multiple resonance peaks in the simulated noise spectrum curves at the microphone position in the noise field test. The field test results of the noise were basically consistent with the trend of the simulation calculation results, which verifies the reliability of the simulation calculation model and provides a reference basis for the vibration and noise suppression of the printing press.