The work aims to systematically elucidate the functional applications and research progress of Metal-Organic Frameworks (MOFs) in the realm of food packaging, to articulate the strengths and challenges of MOFs within the domain of food packaging and offer prescriptive insights for future research directions. A comprehensive analysis of relevant research literature was conducted, covering research on MOFs in key aspects such as gas adsorption, antibacterial preservation, intelligent response, nutrient release, biocompatibility, degradability, and process cost. MOFs demonstrated multiple advantages in food packaging, such as efficient gas adsorption, various antibacterial mechanisms, and intelligent monitoring characteristics. However, there were also issues such as poor stability, high cost, and low consumer acceptance. In conclusion, MOFs hold great potential in the field of food packaging. Despite facing numerous challenges, efforts towards multifunctional integrated design, enhancement of environmental responsiveness and intelligence, in-depth study of biocompatibility and degradability, innovative cost-benefit analysis, and strengthening material synergy are expected to enable MOFs to play a more significant role in this field, leading to innovation and development in food packaging.