The work aims to investigate the influence of different connection molds between the panels and the core layer of honeycomb sandwich structures on the blast resistance. Two configurations of honeycomb sandwich structures, namely, integrated and separated honeycomb sandwich structures, were designed and prepared by laser powder bed fusion technology using 316L stainless steel. Explosive impact experiments were conducted with a 50 mm stand-off distance. Combined with numerical simulation, the dynamic response processes of the four connection molds (integrated, separated, bonded, and welded) under explosive loads were compared and analyzed. The difference of antiknock performance and its influence rule were revealed from the angle of deformation failure of each layer structure, the maximum residual deflection and the energy absorption of the back plate. The maximum residual deflection of the back plate in the integrated honeycomb sandwich structure was 17.5 mm, which was 47.3%, 43.0%, and 28.3% less than that of the separated, bonded, and welded types, respectively. The total plastic strain energy and the back plate strain energy for the integrated honeycomb sandwich structure were 866.9 J and 13.3%, respectively, which were close to those of the welded type. However, its total plastic strain energy was 4.1% and 16.6% lower than that of the separated and bonded types, respectively, and the back plate strain energy was 13.8% and 14.3% lower than the two, respectively. Experimental and simulation studies demonstrate that the strength of the connection in a honeycomb sandwich structure has a significant impact on its blast resistance performance. The integrated structure exhibits the best performance in this regard. Additionally, as the strength of the connection increases, the speed of movement and response time decrease, which is crucial for enhancing the protective structure's vibration damping effect.