The work aims to compare the selection of adhesive materials, and adjust the optimal process parameters of equipment based on the structure of film fastening packaging and automatic production equipment, so as to improve the production efficiency of equipment, and increase the bonding strength between the film and corrugated paper to ensure the stability of packaging transportation and storage. The main technological conditions affecting the bonding strength in the automatic equipment of film fastening packaging were analyzed, and the influence of variables on the bonding strength was explored through the single factor test of adhesive type, adhesive amount, coating pressure, adhesive temperature and curing time. On this basis, the Box-Behnken response surface method was used to optimize the automatic bonding process of film fastening packaging materials. 8335 sealant was selected as the film packing adhesive according to the bonding strength and high and low aging test. With the increase of adhesive amount, the bonding strength showed a linear increase at first and then a slow increase, and reached a critical value when the adhesive amount was 200 g/m2. The bonding strength of the film and cardboard increased gradually and then decreased rapidly. When the gap was 2.4 mm, the bonding strength reached the maximum. The influence of curing time on the bonding strength was small within the equipment space and production speed limit time. At appropriate temperature, the higher the curing temperature, the better the bonding strength. According to the response surface test, the significant degree of influencing factors on the bonding strength of the film fastening packaging was adhesive gap > coating gap > curing temperature. In conclusion, the error between the predicted value and the actual test value of the response surface method regression prediction model is 2.16 %, which indicates that the prediction model is reliable, and the film fastening packaging is more resistant to harsh transportation environments after optimizing the production process parameters than before optimizing, which provides a production reference for improving the reliability of film fastening packaging.