With the development of new materials and new structures, the structure of packaging materials requires higher protection capabilities for products during packaging and transportation. Therefore, the work aims to enrich the structure of packaging materials and design new material structures under the condition of ensuring mechanical properties. Based on the traditional hexagonal honeycomb structure, a new four-hole special-shaped honeycomb structure was designed. Through theoretical analysis, simulation analysis and experimental verification, the mechanical properties of degradable resin specimens were studied. The transverse and longitudinal mechanical properties of the new four-hole special-shaped honeycomb packaging sandwich structure were improved by 17% compared with those of traditional hexagonal and octagonal honeycomb structure, so the structure had better external load carrying capacity. This study gives a new idea for the structure of packaging materials, which is of great support to the development of packaging industry.