The work aims to explore the potential safety risks of water-borne coated paper through screening and safety assessment of semi-volatile migrants in water-borne coated paper. Specific migration tests with 4% acetic acid, 50% ethanol, 95% ethanol and isooctane as food simulants were conducted. Migrants were extracted with methylene chloride solution. Non-targeted screening and quantitative analysis of semi-volatile migrants were performed by gas chromatograph-mass spectrometry (GC-MS), MS-DIAL software and NIST mass spectrometry library, and preliminary risk identification and assessment were performed in combination with specific migration limit (SML) and toxicological threshold of concern (TTC). There were 21 tentatively identified migrants, mainly related to paper raw materials and emulsion additives, such as longifolene, and methyl dehydroabietate, including 7 Cramer Ⅲ substances and 1 Cramer Ⅱ substance. For a small number of substances with SML (e.g., dibutyl phthalate, dioctyl phthalate), the maximum concentration of migrants in 95% ethanol was in the safe range. While the migration of Cramer Ⅲ oleamide and colchicine exceeded the safe threshold of daily intake, posing the potential human risk. In all other conditions, the concentrations of the migrants were below the corresponding Cramer safe threshold. The conclusion of the research is that in the case of prolonged exposure to alcoholic food, more risk substances will be exposed and migrated to the food product, causing potential safety problems.