The work aims to innovatively design the structure of the nozzle pressure relief hole to optimize the vortex formed between the nozzle and the substrate due to airflow impingement which leads to the problem of non-uniformity of wind speed and temperature buildup on the surface of the substrate. A single nozzle simulation model was established by Fluent, and numerical simulation was carried out by the turbulence model to analyze the effect of the nozzle with or without pressure relief hole structure on the drying characteristics of the substrate. Meanwhile, the relative optimal scheme was determined among seven designed structures of pressure relief hole, and the reasonableness of the optimal structure design of nozzle pressure relief hole was verified by setting up an experimental bench. The experimental results showed that by adding the relatively optimal nozzle pressure relief hole structure, the average wind speed in the vortex generating area on the surface of the substrate increased by 3.32 m/s, with the mean square deviation decreasing by 0.86, and the average temperature increased by 24.76 K, with the mean square deviation decreasing by 5.96, which indicated that the nozzle with the design of the relief hole structure could significantly improve the phenomena of lower wind speed and temperature due to the buildup of the vortex flow. The nozzle designed with pressure relief hole has a significant increase in wind speed and temperature in the area between the two slits, and the pressure generation in the vortex area decreases significantly, which improves the phenomena of lower wind speed and temperature caused by vortex between the two slits of the nozzle.