The work aims to analyze milk powder cans from the perspective of food contact materials to provide manufacturers and users of milk powder cans with guidance in terms of compliance management.The composition materials of the can body, the top and bottom covers, the plastic covers, the spoons, and other components were analyzed to study the current states of regulations concerning food contact materials in China, the European Union, and the United States and put forward the compliance management suggestions.There were differences in system design and standard requirements between international and Chinese regulations on food contact materials. The GB 4806 standard series were under revision and had stricter control requirements, and milk powder cans contained more substances of very high concern, both of which presented difficulties for the compliance management of related enterprises. The research and application of non-targeted screening technology in the field of food contact materials provided a reference for the compliance management of milk powder cans. The enterprises related to milk powder cans should pay close attention to the requirements and changes in both international and Chinese regulations on food contact materials and identify the effects of new standards and new substances of high concern on the compliance management of milk powder cans. To better manage compliance of milk powder cans, they should integrate food safety compliance tests, statement of compliance transmission, and application of non-targeted screening technology.