The work aims to study the effects of different drying temperature (40, 50, 60, 70, 80 ℃) on NaHSO3 treatment and drying for 9 h, and determine the most suitable drying conditions for Corydalis yanhusuo before storage. High performance liquid chromatography (HPLC), electronic eye, and other methods were used to determine the quality changes of components in Corydalis yanhusuo. The results showed that under the condition of a drying time of 9 h at 80 ℃, the total ash content significantly increased to 3.47%, and the contents of berberine hydrochloride and berberine hydrochloride reached 0.04% and 0.03% respectively. The highest content of tetrahydropalmatine A and tetrahydropalmatine B was 0.13% and 0.35% at 70 ℃, respectively. The highest content of dehydrocolline was 0.42% at 60 ℃. When the drying temperature was 50 ℃, the highest content of alcohol soluble substance was 21.84%. As the drying temperature increased, the effects of temperature on protoopioid alkaloids and palmatine hydrochloride were not significant. However, the browning of Corydalis yanhusuo became more severe. The optimum drying temperature of Corydalis yanhusuo before storage is 40~60 ℃, at which the moisture content of Corydalis yanhusuo was less than 6%. Therefore, an appropriate drying temperature can maximize the quality of Corydalis yanhusuo during its later preservation and storage period, thereby extending its shelf-life and providing theoretical support for maintaining good quality of Corydalis yanhusuo.