At present, the model predictive fault-tolerant control of single-phase open fault of six-phase permanent magnet synchronous motor has gradually become a hot topic. The work aims to comparatively analyze the fault mechanism under α-β and d-q coordinate system control and compare the control effect of normal and fault-tolerant operating models in different coordinate systems. Based on the vector space decoupling coordinate transformation matrix invariant principle, the A-phase open fault model was theoretically calculated and analyzed, and the model predictive control fault-tolerant modeling was carried out in two different coordinate systems, α-β and d-q respectively. Finally, in MATLAB/Simulink, the same motor parameters were used for real-time simulation of the normal operation and fault-tolerant operation of the motor in the two coordinate systems. The simulation results showed that under normal operation, the THD was 2.09% and 2.77% respectively. In fault operation, the THD in α-β coordinate systemwas 13.15% smaller than that in d-q coordinate system. In fault-tolerant operation, THD was 1.19% and 1.79% respectively in the two coordinate systems. It can be seen from the simulation results that the motor controlled by d-q coordinate system has more stable performance when fault occurs, and the control effect under normal and fault-tolerant operation conditions is almost equivalent.