In view of the current situation that each type of vehicle requires a dedicated packaging box, the work aims to design a new type of general packaging box that can meet the transportation and lifting requirements and adapt to a variety of vehicles. The structure of the packaging box was designed according to the design requirements. The transportation and lifting conditions were analyzed with finite element analysis methods and engineering algorithms and the reliability, safety, maintainability and supportability were analyzed. It was obtained that the maximum stress of the steel skeleton of packaging box was 166 MPa and 215 MPa under the condition of transporting and lifting the product of the maximum mass, which was smaller than the yield strength of the material, meeting the strength requirements and ensuring high reliability, safety, maintainability, and supportability. This structural design of packaging box meets the design requirements and the packaging box can be used for transportation of vehicles of different sizes with lower design costs.