The work aims to study the difference of random vibration of Gaussian excitation force and non-Gaussian excitation force on packaged goods, to provide random vibration test methods and parameters, and to provide optimization suggestions for the design of commodity transport packaging. The development trend of random vibration technology was studied by means of scientific metrology. By increasing kurtosis, non-Gaussian vibration simulation random vibration test was carried out. The relationship between random vibration intensity and fatigue damage expression by power spectrum density and random vibration test time was studied. ISTA 3A-2018 Packaged-Products for Parcel Delivery System Shipment 70 kg (150 lb) or less was preferred for the detergent products sold by e-commerce channels through express delivery. Random vibration test was carried out by the Over-The-Road Trailer spectral and the Pick-up and Delivery Vehicle spectral. Accelerated simulation test and enhanced simulation test were carried out by kurtosis loading. Under the condition of kurtosis of 5, 7 and 9, the cargo damage of the goods in actual distribution can be reproduced. The modified package design scheme based on the test results can protect goods under the condition of strengthening the simulation test. The omni-channel supply chain should adopt efficient and scientific laboratory testing methods to provide methods and data for transportation package design and verification.