The work aims to establish an ICP-MS method to detect 12 elements in plastic spray pump, and determine the contents of elements in hydroxymethazoline hydrochloride spray.The method of microwave digestion was used for sample pretreatment, and 12 elements including boron, aluminum, titanium, chromium, manganese, iron, zinc, nickel, arsenic, molybdenum, cadmium and lead in plastic spray pump were tested by ICP-MS. For each element, there was a favorable linearity in the range of 0-500 ng/mLwith the correlation coefficients r>0.99. The detection limit of this method was 0.02-1.71 µg/kg, the rate of recovery was 92.62%-113.82% and the relative standard deviation (RSD) was 0.64%-3.41%. At the same time, with hydroxymethazoline hydrochloride spray as an example, the content migration of elements in the spray was studied under the condition of acceleration, and the results showed that all elements did not exceed the concentration limit. This method established in this work is convenient for sample pretreatment, accurate and highly sensitive and can determine the contents of 12 elements in plastic spray pump rapidly and efficiently.