The work aims to analyze the factors influencing the diffusion coefficient (Dc) of hazardous monomers in bamboo fiber/melamine composite products and to explore the pattern of variation of their specific migration amounts and the mechanism of interfacial migration. In this paper, with bamboo fiber/melamine tableware of the same raw materials and different processes as test sample, the relationship between the content, specific migration, material structure and diffusion coefficient of melamine and formaldehyde residue monomers in bamboo/melamine products and their effect were investigated with liquid chromatography, UV spectrophotometer and scanning electron microscope/energy dispersive spectrometer (SEM/EDS). The presence of interfacial structures and differences in residual monomer concentrations in samples made by different processes were the main intrinsic factors affecting the diffusion coefficient Dc of monomers. The diffusion coefficient DC was a variable that resulted from the combined effect of the interfacial concentration factor of the monomer and the structural factor of the material. As the immersion time increased, the simulated liquid caused damage to the surface structure of the material, which drove the diffusion coefficient DC to become larger. At the same time, the concentration of monomers within the material was also changing, and the combined effect of monomer concentration and interfacial structure caused the diffusion coefficient DC to increase or decrease.During the testing of bamboo fiber/melamine composite products for specific migration of monomers, the diffusion coefficient DC is influenced by changes in the interfacial structure, and the pattern of changes in the values of specific migration is verified, providing a reference for evaluating the safety of bamboo fiber/melamine tableware.