The work aims to study the changes in the compressive strength of corrugated cartons, improve the efficiency of corrugated carton recycling, and reduce the waste of resources. Through finite element simulation, the compressive strength of corrugated cartons at different humidity levels and the stress on corrugated cartons during vibration were simulated. The compressive strength of corrugated cartons was tested by means of experiments to summarize the law of change in compressive strength. The finite element analysis showed that the higher the humidity, the lower the compressive strength of the corrugated carton and the greater the stress during vibration. The test showed that the higher the humidity, the lower the compressive strength and the greater the reduction in compressive strength when the vibration time was the same. The compressive strength related formulae derived from finite element and test methods are used to judge whether corrugated cartons can continue to be recycled or not, which can effectively improve the recycling efficiency of corrugated cartons.