The work aims to construct a four-layer architecture model of monitoring system based on digital twin to solve the problems of single function, low visualization and low information utilization of monitoring systems in gravure printing production. On the visual monitoring platform, a virtual scene of the gravure printing machine was built with SolidWorks, 3DS Max and Unity 3D modeling software. The real-time data of the equipment were collected based on the Modbus TCP/IP protocol. The SQL Server database was used to realize classified storage of equipment data, and the virtual-real mapping logical structure of gravure printing machines was combined to write C# scripts to realize the synchronous mapping between the physical entity and the virtual model. Finally, the monitoring system was developed. The platform realized the functions of virtual-real synchronous operation, condition monitoring, register deviation monitoring and health management of gravure printing machines, which provided a feasible scheme for intelligent operation and maintenance of printing enterprises. Compared with the traditional printing equipment monitoring, the monitoring system based on digital twin breaks through the time, space, input cost and other conditions. Operators can grasp the production information, operation status and historical information of gravure printing machines in real time, which greatly improves the efficiency of stable production of equipment and reduces the cost of enterprises.