In view of the urgent demand for digital, automatic and intelligent equipment in the upgrading of pharmaceutical glass packaging industry at present, the work aims to propose an automatic packing method for pharmaceutical glass bottles (penicillin bottles, ampoule bottles, oral liquid bottles, etc.) to reduce labor intensity and improve product quality. With ampoule bottle as an example, on the basis of full analysis of the specific requirements, the computer aided design technology and simulation technology were combined with the method of "top-down" design to complete the mechanical design and motion simulation on the 3D model of the system. PLC industrial control technology was employed to establish the control model compatible with production lines for different specifications of products, so as to realize the intelligent control of the system, and complete the trial production of the prototype. After successful application in several large pharmaceutical glass packaging enterprises in China, the automatic packing system for pharmaceutical glass bottles developed could effectively reduce the scratches and pollution caused by traditional packing method, reduce the cost of packaging personnel by 40% and improve the qualified rate of products by 5%. The automatic packing system for pharmaceutical glass bottles can significantly improve the quality of products, reduce labor costs, and accelerate the process of automation and intelligence in the industry.