The work aims to propose a solution method of the internal force of the wooden frame structure by taking the wooden frame structure for heavy-duty packaging and transportation as the research object. With 4X frame structure as an example, the empirical simplified statically determinate truss and non-simplified statically indeterminate truss were theoretically solved by analytical method. Based on ANSYS software, empirical simplified statically determinate truss, non-simplified statically indeterminate truss, beam model, beam and rod combination model and solid model were established respectively, and comparative analysis was carried out. The results of finite element analysis were highly consistent with those of analytical method. The maximum axial force of empirically simplified statically determinate truss exceeded the maximum axial force of non-simplified statically indeterminate truss by 15%. The calculation results of beam model, beam and rod combination model and solid model were highly consistent with those of the non-simplified statically indeterminate truss. The simplification of frame structure by empirical method often leads to large errors, resulting in over packaging design or under packaging design. The modeling process of beam and rod combination model and solid model is relatively complex. The beam element is selected for numerical calculation and analysis of the frame structure for wooden box, which not only has high calculation accuracy and fast analysis processing, but also has good adaptability to complex working conditions.