The work aims to conduct a more in-depth exploration on the current research of nano-composite food contact materials (NFCM), in order to promote the integrated development of food packaging in functional, intelligent and green ecological terms. The diversified development of NFCM was firstly summarized and the impact of nanotechnology on the mechanical strength, gas barrier, antibacterial preservation, intelligent activity monitoring and biodegradation properties of NFCM was outlined. Then, the migration behavior of nanomaterials from NFCM under actual working conditions (ambient temperature, contact time and food pH) was analyzed deeply. Finally, the potential toxicity of nanomaterials on human cells and tissue organs was explored, which was the key factor in the safety assessment of NFCM. Modern nanotechnology improves the performance of flexible polymer and realizes the multifunction of NFCM. This has broad application prospects in food packaging for meat, bread, fruits and vegetables, and also provides reference value for the development of food packaging industry.