The work aims to solve the problem that the multi-motor cooperative control is easily affected by uncertain factors such as nonlinearity and external interference. Based on the multi-motor deviation coupling control structure, the hybrid non-singular end sliding mode with disturbance compensation was combined with the variable structure control to conduct simulation comparison with the traditional PI (Proportional Integral) regulator in terms of control effect. Focusing on the verification and analysis of the proposed control algorithm by computer simulation software, it could be concluded as follows. First, when the overall disturbance was encountered, the speed error could be improved by 8.50% compared with the traditional PI control. Specifically, when the motor torque was disturbed, the control effect was more ideal, in which the new load torque value can be reached with almost no lag time. In addition, when load disturbance occurred, the speed error fluctuation was smaller, which was improved by about 8.83% compared with traditional PI control. In general, according to verification through computer simulation, the hybrid non-singular end sliding mode variable structure control system with disturbance compensation is superior to the traditional PI control in response time, convergence speed, control performance and robustness.