The work aims to develop a remote temperature monitoring system for information-based intelligent packaging to meet the needs of information visualization and transparency in the last kilometer of vaccine transportation. By combining the Internet of Things technology, a LoRa gateway between the sub computer node and the host computer based on the GD32F330C8T6 chip as the core, and the upper computer software based on the Qt Creator 5.12 software and SQLite database were designed. Finally, a specific example of remote temperature monitoring system was realized, and the hardware of the sub computer node was embedded in the vaccine refrigerator. The multi point temperature measuring probes were placed at different positions in the refrigerator to monitor the temperature range in the vaccine refrigerator. Through the remote temperature monitoring system, users can monitor the temperature of different refrigerators in the transport vehicle in real time. The overtemperature system can automatically close the host relay module to open the external cooler, realizing the intelligent packaging of vaccine refrigerators.