In the gravure printing with laser column paper as the printing material, the laser column interferes with the color label detection sensor, causing the laser column paper unable to be printed by the traditional overprinting process. Therefore, the work aims to propose a new process and technology solution to print the registration color label directly in the laser column area. The detection principle of the color label sensor was analyzed, and the characteristics of the laser column paper and the interference caused to the color label sensor were analyzed. The filter lenses were selected based on the spectral reflectance graph of the laser column, and the attenuating lenses and extinction films were also combined for the experimental measurement of voltage, which was carried out by the Songde gravure printing machine set. Different combinations of lenses were selected for production proofing with the ivory board overprint voltage as a reference. The combined lenses could filter out the laser column, the color label sensor could accurately detect the color light signal, and the onboard proofing met the high precision multi-color overprinting. In addition, complicated hollowing and masking process were not required, which saved a set of color sequence and 2% of printing raw materials. The analysis on the detection principle of the color label detection sensor and the measurement of the spectral reflectance curve of the laser column paper enable the filtering of the laser column by a combination of filter lenses and demonstrate the feasibility of printing the registration label directly in the laser column area. At the same time, the utilization of printing materials is improved and the amount of ink used is reduced.