The work aims to enhance the quality of prepared food and facilitate the sustained growth of the prepared food industry. From the production and processing chain of prepared food, the potential safety hazards and corresponding solutions in the raw material selection, production and processing, packaging, transportation, and storage were analyzed. It was found that the prepared food was contaminated by bacterium at various stages of production and circulation. The harm of the bacterium to the human body could not be underestimated. Finally, the application of non-heat sterilization technology in improving the quality and safety of the prepared food was summarized. It is found that the improvement of prepared food safety not only depends on controlling the quality of raw materials, but also on studying and exploring sterilization technologies, which makes collocation more scientific, food ingredient fresher, and processing more accurate.